SYNTHESIS OF TERMINAL 2-ALKENYL(ALKYNYL)THIO-5-CYANO-6-(p-DIMETHYLAMINOPHENYL)PYRIMIDIN-4-ONES

Functionalized pyrimidines possess a wide spectrum of biological activity. In particular, they have antitumor, antiviral, and anticonvulsant activities, exhibit anti-inflammatory analgesic effects, are inhibitors aldose reductase, SecA ATPase, azide, plant growth. The search for methods synthesis new functionalized condensed pyrimidine derivatives is an urgent problem.
 Alkenyl-functionalized mono- polycyclic promise substrates studying the regioselectivity electroph ilic heterocyclization reactions under influence halogen-containing electrophilic agents, halogen- chalcogen-functionalized cyclization products showed high antibacterial, antifungal, antimalarial introduction functional groups capable to modification into such alkenylpyrimidines can significantly affect their reactivity change/enhance activity halocyclization products. We proposed 2-alkenyl(alkynyl)thio 5-cyano-6-(p-dimethylaminophenyl)-pyrimidin-4-one containing cyano group labile functionalization. As result alkylation 2-thioxo-5-cyano-6-(p-dimethylaminophenyl)pyrimidin-4-one with unsaturated alkyl halides in alkaline medium, terminal alkenyl (allyl, methallyl) alkynyl (propargyl) thioethers cyanopyrimidine were obtained, promising reagents .
 Keywords: 2-thioxo-5-cyano-pyrimidin-4-one; alkylation; alkenylthiopyrimidinone; alkynylthiopyrimidinone.